With the growing global demand for fish as a protein source, there’s increasing pressure to find sustainable alternatives to traditional aquafeed ingredients like fishmeal (FM) and fish oil (FO), which are facing reduced availability due to environmental and economic constraints. Plant-based substitutes help ease the burden on marine ecosystems but come with challenges such as anti-nutritional factors, low levels of essential omega-3 fatty acids (EPA and DHA), limited amino acid profiles, and reduced palatability—ultimately affecting fish growth, health, and product quality. Moreover, only a few crops like soybean, rapeseed, corn, and wheat are commonly used in aquafeeds, and their availability is influenced by climate change and global socio-economic factors. These plant-based ingredients also compete with human food, livestock, and pet food markets, driving up prices and limiting supply for aquaculture. Novel feed ingredients like insect meals, single-cell proteins, and fish co-products are being explored but are still limited by regulatory, cost, and scalability issues. Antarctic krill (Euphausia superba) stands out as a promising low-trophic alternative with minimal environmental impact, sustainable sourcing as it’s the most sustainable fishery, aligning with industry standards and consumer demands for eco-friendly products. Moreover, since krill is not consumed by humans, there is no competition between its use for food and feed . Further k rill-derived products mainly krill meal (KM) are rich sources of nutrients such as highly digestible proteins and lipids , phospholipids, astaxanthin, and phospholipid-bound omega-3s (EPA and DHA), which are more bioavailable than those in traditional sources and micronutrients such as organic minerals and vitamins . Further, commercially available KM is supported by extensive scientific evidence demonstrating its benefits in various fish species when included in feeds. This review consolidates current knowledge based on 22 nutritional studies from the 1980s to the present on the benefits of KM for the most important non-salmonid fish species to aquaculture, including Gilthead seabream (Sparus aurata), European seabass (Dicentrarchus labrax), Nile tilapia (Oreochromis niloticus), red seabream (Pagrus major ), Olive flounder (Paralichthys olivaceus), and yellowtail ( Seriola quinqueradiata) (Figure. 1). In addition, this review addresses the possible future perspectives on the application of krill meal in aquaculture feeds. Finally, the review addresses the key challenge of KM’s high cost, highlighting the need for comprehensive economic evaluations to assess its cost-effectiveness compared to both conventional and novel feed ingredients.