Maintaining gut health is essential for optimal growth, feed efficiency, and disease resistance in aquaculture species. Inflammatory bowel conditions, whether caused by pathogens, diet, or environmental stressors, represent a major threat in intensive aquaculture systems. This study aims to investigate the effects of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in zebrafish as an in-vivo model for acute intestinal inflammation and assess the potential mitigating effects of dietary beta-glucans , as shown in Figure 1.
Beta-glucan s are complex polysaccharides derived from yeast and other fungal cell walls . They are known immunomodulators and have demonstrated anti-inflammatory properties in various animal models. Beta-glucans can increase macrophage functionality and mobilise other immune cells including natural killer cells, which play a crucial role in controlling inflammation and infection. We hypothesize that dietary supplementation with beta-glucans can reduce TNBS-induced inflammation in the posterior intestine of zebrafish, potentially by modulating innate cellular responses and preserve intestinal integrity.
This model will serve as a foundation for developing functional feeds that support intestinal health in commercially important aquaculture species. Results from this research may contribute to sustainable health management strategies in fish farming.